piRNA

Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons

The Piwi-interacting RNA (piRNA) pathway safeguards genomic integrity by silencing transposable elements (transposons) in the germline. While Piwi is the central piRNA factor, others including Asterix/Gtsf1 have also been demonstrated to be critical …